TNF and rheumatoid arthritis: Four trials enrolled patients with disease durations no more than 6 months and these showed a similar benefit for intensive treatment (RR 1.47; 95%CI 1.03, 2.10) Comparison of the different intensive treatment regimens in early RA patients showed similar impacts of different intensive treatments; these ranged from a random risk ratio of 1.43 with TNF inhibitors to 2.00 with other biologics.