Other gene mutations causing ADTKD include mucin 1 (MUC1), hepatocyte nuclear factor 1 beta (HNF1b), renin (REN), and the alpha subunit of the endoplasmic reticular membrane translocon (SEC61A1) [3–7]. The gene discussed is REN; the disease is autosomal dominant medullary cystic kidney disease with or without hyperuricemia.