ITGA4 and Sepsis: This supports the idea of a non-classical activation phenotype, rather than the rise of an immature neutrophil subset in the blood such as also has been described in sepsis patients.[48] Recently, also a circulating CD49dbright pro-angiogenic neutrophil phenotype has been described in mice in response to hypoxia-induced VEGF-A signaling.[33] It is possible that the neutrophils present at day 5–8 after cycling upregulate their CD49d because they are exposed to both DAMPs originating from limited reperfusion as well as hypoxia signals.