INS and type 1 diabetes mellitus: The lack of insulin stimulatory effect on FollicleStimulating Hormone (FSH) in experimental type-1 diabetes may also play a role inthe decreased Leydig cell function and testosterone production (Ballester et al., 2004); giventhat insulin replacement significantly improved sperm quality and testicularcytoarchitecture in diabetic rats (Seethalakshmiet al., 1987; Soudamani et al., 2005).