RYR2 and hydrops fetalis: Overall RyR expression was similar in Sham and HF, as evidenced by Western blotting of ventricular homogenates (Figure 2— figure supplement 1), and equivalent RyR labeling density in cardiomyocytes (41.9 ± 1.4 RyR/μm, 40.4 ± 1.3 RyR/μm in Sham, HF respectively).