HLA-DQB1 and systemic lupus erythematosus: It is estimated that 5 per 10,000 of those taking minocycline develop lupus through binding to tissue macromolecules, which leads to immunogenic cross-reactivity11, and HLA-DQB1, HLA-DR2 or HLA-DR4 have been implicated in minocycline-induced lupus12.