CDKN1B and neoplasm: Immediate translational clinical trials of our pre-clinical findings (underway at our institution) pose few logistical challenges as the treatment is safe, the patients may be stratified by prior examination of tumor GR expression in multiple core biopsies, routine radiological monitoring could be used to examine the effect of Dex and p27Kip1 could be measured as a biomarker of Dex-induced senescence.