Nik-Zainail et al. carried out a large-scale analysis of the whole genome of 560 breast cancers, and identified 916 probable driver mutations including TP53, PIK3CA, MYC, CCND1, PTEN, ERBB2, ZNF703/FGFR1, RB1, and MAP3K1 as the most frequently mutated genes14. Here, RB1 is linked to breast cancer.