As mentioned, the effect of JunB knock-down also differed in cHL cell lines with the proliferation defect being more pronounced in L-540 and L-428 cells than KM-H2 cells (Figs 2 and 3; Table 1) further demonstrating that the importance of JunB in regulating proliferation varies amongst cHL and ALK+ ALCL cell lines. This evidence concerns the gene ALK and anaplastic large cell lymphoma.