Thus, the different outcomes associated with c-Jun knock-down in these two lymphomas could be a result of c-Jun regulating critical proliferation–associated genes in cHL that it does not in ALK+ ALCL, or that the amount of c-Jun present in the c-Jun knock-down cells is sufficient to promote proliferation in ALK+ ALCL but not cHL. Here, JUN is linked to anaplastic large cell lymphoma.