For example, NF-κB6,7, STATs8,9, GATA310,11, and IRF512 play important roles in cHL pathogenesis, whereas PU.1 (SPI1)13,14, EBF115,16, and FOXO117 function as tumour suppressors in this lymphoma and are repressed. The gene discussed is SPI1; the disease is classic Hodgkin lymphoma.