SHP2 cancer mutants (SHP2G60V, SHP2D61V, SHP2E76K, SHP2F285S, and SHP2S502P) introduced into PTPN11-null U2OS cells were expressed in amounts comparable to the reintroduced SHP2WT in the SHP2-null cells (Fig. 6a). Here, PTPN11 is linked to cancer.