TCF12 and Saethre-Chotzen syndrome: We report in this study the generation of a zebrafish model of Saethre-Chotzen syndrome that faithfully recapitulates the craniosynostosis phenotype seen in mice and humans with heterozygous mutations in TCF12 and TWIST1. The similarity in the genetic interaction between Twist1 and Tcf12 in mice, humans, and fish, despite differences in the cell lineages that give rise to the bones, suggests that the underlying processes of coronal suture development and craniosynostosis are deeply conserved.