While we did not perform biodistribution studies to determine if the increased PSMA levels led to a higher tumor uptake of 177Lu-PSMA617, preclinical evaluation of 68Ga-PSMA11/177Lu-PSMA617 by Umbricht et al. demonstrated very similar uptake and internalization of the 68Ga- and 177Lu-ligand, respectively, by PC-3-PIP cells [20]. The gene discussed is FOLH1; the disease is neoplasm.