To conclude, paraneoplastic neurological syndromes in patients seropositive for onconeural antibodies are not associated with significant alterations of serum NSE and S-100B levels, with the exception of the subgroup without clinically active malignancy and also, for S-100Β only, in the subgroup of patients with peripheral PNS manifestation. Here, ENO2 is linked to paraneoplastic neurologic syndrome.