AKT1 and gastric cancer: Distinct deletion SCNAs for Chinese EAC include the following regions: 1p36.21, containing (i) MTOR, a central regulatory kinase dysregulated in gastric cancer and activated by PI3K/Akt (including aforementioned AKT-3) and insulin-like growth factor receptor (including aforementioned IGF1R)38, and (ii) CHD5, a tumor suppressor gene in gastric cancer39.