RUNX1 and acute myeloid leukemia: Several acute myeloid leukemia (AML) predisposition syndromes are caused by innate mutations in transcription factors that affect embryonic hematopoiesis, such as Gata2 and Runx1 (Babushok et al., 2016), suggesting that perturbations in embryonic hematopoiesis affect the adult HSC compartment.