TP53 and glioblastoma: Alterations in EGFR, PDGFRA, PTEN, TP53, NF1, CDKN2A/B, and TERT promoter mutations are commonly found in primary glioblastoma, while the prevalence of IDH mutations is high in grades II and III astrocytomas, secondary glioblastoma, oligodendrogliomas, and oligoastrocytomas (10).