AKT1 and nervous system disorder: In summary, our findings investigated the in vitro neuroprotective effects and mechanism of ATX against Hcy-induced neural toxicity, and the results suggested that ATX has the potential to reverse Hcy-induced neurotoxicity and apoptosis by inhibiting mitochondrial dysfunction, ROS-mediated oxidative damage and regulation of MAKPs and AKT pathways, which validated the strategy of using ATX could be a highly effective way in combating Hcy-mediated neurological disorders.