Similarly, we also identified several of the EEA genes including, FOXM1, PLK1, BUB1, KIF2C, CDCA2, CDC20, CDKN3, KNL1 to name a few, that are known for their role in CIN and tumor development.35–43 This may reflect a selective pressure for additional genetic alterations in early tumors that would allow their further evolution. This evidence concerns the gene BUB1 and neoplasm.