SOD and Portal hypertension are important risk factor of GSD as reported by Chawla et al and Sarin et al, was not assessed in our study [23, 24] Although ethnicity was considered in our study but it was a single center study based on study population of a city, so there is further need of large multicenter study to assess true frequency and prevalence of gallstones with respect to ethnicity in our country. This evidence concerns the gene SOD1 and portal hypertension.