Mechanistically, NEAT1 recruits EZH2 to form the PRC2 complex and mediate the expression of EZH2 target genes, thereby promoting tumor cell growth and invasion in glioblastoma and cholangiocarcinoma (Chen et al., 2018; Zhang C. et al., 2018; Figure 4 and Table 1). Here, EZH2 is linked to glioblastoma.