While Al-Shibli et al. (36) identified both tumor-infiltrating CD4+ and CD8+ T cells as independent favorable prognosis markers, the Hiraoka et al. (35) study identified that a concomitant infiltration of tumors by CD8+ and CD4+ T cells, but not CD8+ T cells alone, was associated with better prognosis. Here, CD4 is linked to neoplasm.