LRRK2 (PARK 8) is hypothesized to play a role upstream of the MAPK pathway and to mediate both familial and sporadic Parkinson’s disease by inducing intrinsic neuronal apoptosis (Zimprich et al., 2004; Healy et al., 2008; Lin et al., 2009). Here, LRRK2 is linked to Parkinson disease.