TLR8 and infection: It is thus relevant that among transcripts up-regulated by infection with the “disseminating” clades A and C, but to a lesser extent clade B (localized disease), are a number of macrophage heat shock or stress response proteins, whereas transcripts relevant to inflammatory response pathways (TLR8, STAT1, TNFSF13B, SYK) in macrophages were down-regulated.