Although the direct effect of FGF21 on liver is still controversial because of the lack of an FGF receptor 1 in hepatocytes, NAFLD might be alleviated through the effect of training on adipose tissues: namely, the development of brown fat-like cells in white adipose tissue (the “beiging” phenomenon) and increased levels of adiponectin (134, 135). This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatotic liver disease.