EGFR and neoplasm: In another study, Zhang et al. (2010) have demonstrated that sub -30 nm HDL mimicking NPs, functionalized with an EGFR targeting ligand, preferentially accumulated in the tumor interstitial spaces, suggesting that the small size, neutral surface charge, specific targeting ligand and long circulation half-life were instrumental in successful extravasation of the NPs into the tumor mass (Zhang et al., 2010).