This experimental design will bring about our focus on the most translational component of our research, as will focus first in demonstrating if one can find in the CORT model of depression changes in the clustering pattern of SERT and 5HT2A that are similar to those found in naïve depression patients, and if so use this approach to analyze the patterns of clustering of other proteins that can thereby be screened for further analysis in depression patients (using a bedside to bench to bedside approach). The gene discussed is SLC6A4; the disease is depressive disorder.