In addition, reelin is also involved in dendritogenesis, spinogenesis, and regulation of LTP, which are other forms of plasticity altered in depression, thereby indicating the interest in studying both central in peripheral actions of reelin within the context of depression, and fostering the interest in the study of the possible antidepressant-like characteristics of reelin peptides (Caruncho et al., 2016). The gene discussed is RELN; the disease is major depressive disorder.