One well-characterized model makes use of repeated injections of corticosterone (CORT), which results in a robust and reliable increase in depression-like behavior as ascertained by different behavioral paradigms (Kalynchuk et al., 2004; Gregus et al., 2005; Marks et al., 2009), and a concomitant decrease in both adult hippocampal neurogenesis and expression of the extracellular matrix protein reelin in the proliferative subgranular zone of the dentate gyrus (Lussier et al., 2009, 2011, 2013). This evidence concerns the gene RELN and major depressive disorder.