In a similar way, we have also shown that the therapeutic outcome of antidepressant treatment in depression can also be predicted by alterations in SERT clustering in lymphocytes in naïve patients and proposed that a SERT clustering assay could be used as a biomarker of therapeutic efficacy in major depression (Rivera-Baltanas et al., 2012, 2015). Here, SLC6A4 is linked to depressive disorder.