These series of hypotheses-based studies (bench to bedside to bench) initiated with the demonstration of altered patterns of SERT clustering in animals with low levels of reelin (Rivera-Baltanas et al., 2010) and the demonstration that those animals are more susceptible to some behavioral alterations induced by CORT (Lussier et al., 2011), followed by the demonstration of altered patterns of SERT and 5HT2A clustering in naïve depression patients and its proposal as putative biomarkers of therapeutic efficacy for major depression (Rivera-Baltanas et al., 2012, 2014, 2015). The gene discussed is RELN; the disease is depressive disorder.