RELN and depressive symptom measurement: One well-characterized model makes use of repeated injections of corticosterone (CORT), which results in a robust and reliable increase in depression-like behavior as ascertained by different behavioral paradigms (Kalynchuk et al., 2004; Gregus et al., 2005; Marks et al., 2009), and a concomitant decrease in both adult hippocampal neurogenesis and expression of the extracellular matrix protein reelin in the proliferative subgranular zone of the dentate gyrus (Lussier et al., 2009, 2011, 2013).