Indeed, experiments with brain hepcidin knockout have resulted in decreased brain iron content in models with brain hemorrhage, while BMP/SMAD pathway suppression has recently been used in animal models to treat iron overload caused by hepcidin upregulation during brain ischemia (Ding et al., 2011; Tan et al., 2016; Shin et al., 2018). Here, HAMP is linked to intracranial hemorrhage.