TLR4 and Parkinson disease: On the other hand, role of inflammation in AD and PD is characterized with subtle but important differences between these conditions; in vivo models with mice have shown that Aβ oligomer accumulation in AD is related to TLR4 activity, which is in contrast with α-synuclein accumulation in PD, where the role of TLR4 is low or inexistent (Noelker et al., 2013; Forloni et al., 2016; Calvo-Rodríguez et al., 2017).