Interestingly, a novel missense mutation (histidine to arginine at 705 amino acid) in GNE gene (UDP N-acetylglucosamine 2 epimerase/N-acetyl Mannosamine kinase) was observed in familial ALS patient (Köroğlu et al., 2017). The gene discussed is GNE; the disease is amyotrophic lateral sclerosis.