The majority of these AESIs were nonspecific events including sedation, reported by 6.5% of patients receiving BUP/SAM 2 mg/2 mg and 0.7% receiving placebo, somnolence in 7.3% and 3.5%, respectively, and dizziness in 12.2% and 3.9%, respectively. Here, COMMD3 is linked to Coma.