Our findings are in line with the well-documented tumour-suppressor role of GAS5, through the inhibition of cell proliferation and the stimulation of apoptosis, in the wide range of human malignancies studied so far.16,17,41–45 Repression of GR transcriptional activity15,23 and miRNA sponging,46–50 have been proposed as the main molecular mechanisms underlying GAS5 tumour-suppressor function. This evidence concerns the gene GAS5 and neoplasm.