Indeed, GAS5 silencing is associated with increased proportion of cells in the S/G2 phase as well as with attenuated apoptosis upon endogenous stimuli or chemotherapeutic agents.20–22 The main molecular mechanisms of GAS5 tumour-suppressor activity are riborepression of glucocorticoid receptor (GR) transcriptional activity and “sponging” of oncogenic miRNAs.16,17,23. This evidence concerns the gene GAS5 and neoplasm.