In our studies, IL6 upregulation, seen after BP3 treatment, matches with improved insulin sensitivity, obesity and steatosis in IL6 transgenic mice58,61,62, likely by suppressing gluconeogenic and lipogenic enzymatic cascade via hepatic STAT3 phosphorylation (see scheme in Fig. 6). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.