For example, whereas corticosteroids used for treatment of inflammatory bowel disease have well-documented side-effects resulting in impaired glucose regulation, biologicals such as tumor necrosis factor-α antagonists may alleviate inflammation and therefore potentially improve glucose regulation (Antohe et al., 2012; Parmentier-Decrucq et al., 2009; Solomon et al., 2011; Tam et al., 2007). This evidence concerns the gene TNF and inflammatory bowel disease.