IL12B and lung cancer: Furthermore, we isolated F4/80+ TAMs from PBS- or HCQ-treated mice with orthotopic lung cancer, and we found that the M1-like molecules (Nos2 [24], Ifng, IL12b,and IL1b) were up-regulated and the M2-like molecules (Arg1 [25], Tgfb1, IL10, and Ido1) were down-regulated with HCQ treatment (Fig. 6b).