SDC1 and infection: Considering the presence of MUC16 in the upper respiratory tract of pigs, and given the previously described function of SDC-1 in adhesion to and invasion of epithelial cells [36, 37], the role of Zmp in the pathogenesis of S. suis serotype 2 infection, more particularly in colonization, as well as its role as a virulence factor, were evaluated using an intranasal piglet model of S. suis infection.