Herein, we compared the biomarker performance of two methylation panels [panel #1 (miR-193b/miR-34b/c) and panel #2 (APC/GSTP1/RARβ2)], for PCa diagnosis and prognostication, in the same series of prostate biopsies and urine sediments, from two independent cohorts. The gene discussed is APC; the disease is posterior cortical atrophy.