Indeed, besides representing promising PCa detection/diagnostic biomarkers, several studies demonstrated that gene promoter hypermethylation might add relevant prognostic information, such as GSTP1 promoter methylation which independently predicted recurrence after radical prostatectomy [12] and higher APC promoter methylation levels which also showed independent prognostic value in addition to tumor stage [13]. The gene discussed is APC; the disease is posterior cortical atrophy.