Tg-induced thyroiditis is a classic model for studying HT [24] and can be established in susceptible mice, such as NOD mice, leading to the development of HT-like illness characterized by monocyte infiltration into the thyroid gland and presence of autoantibodies against Tg and TPO, which are serological hallmarks of HT [2]. The gene discussed is TPO; the disease is thyroid gland disorder.