Therefore, our observations revealed the multifaceted features of apigenin in the suppression of melanoma growth, which were exerted either directly through growth inhibition and apoptosis induction, or indirectly but more potently through regulating immune responses in the tumor microenvironment as well as boosting host immunity, both in a PD-L1 expression dependent manner (Fig. 8). This evidence concerns the gene CD274 and neoplasm.