There is one subgroup analysis from the GeparSixto trial that showed a significant benefit for histological grade 3 vs. grades 1–2 if platinum treatment was added in TNBC and HER2-positive BC (OR for G3, 1.73; 95% CI, 1.15 to 2.60; OR for G1–2, 0.776; 95% CI, 0.432 to 1.40; Pinteraction = 0.027) [35]. This evidence concerns the gene ERBB2 and breast cancer.