BRCA1 and neoplasm: In one analysis, the addition of platinum significantly increased the pCR (ypT0is/ypN0) rate from 36.6 to 63.2% in HRD tumors with intact BRCA1/2 function in tumor tissue (P = 0.018), marginally from 61.9 to 72.7% in BRCA-mutated tumors (P = 0.406), and moderately from 20.0 to 40.7% in non-HRD tumors (P = 0.086).