BRCA1 and neoplasm: Systemic treatment for TNBC has been restricted mainly to conventional chemotherapy in the past [8–10, 14, 17], but new targeted therapies such as immune-checkpoint inhibitors [18] and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors [19, 20] have been under investigation in clinical trials, which are suitable for subgroups of TNBC patients with a germline BRCA1/2 mutation or a homologous recombination deficiency (HRD) in the tumor [7, 14, 21, 22].