In the GeparSixto trial (NCT01426880) investigating the effect of adding platinum to doxorubicin/paclitaxel in patients with TNBC and HER2-positive BC, there was a significant increase in the pCR rate in TNBC, from 36.9 to 53.2%, with the addition of platinum (OR 1.94; 95% CI, 1.24 to 3.04; P = 0.005), while there was no significant effect in HER2-positive BC, at 36.8% vs. 32.8% with the addition of platinum (OR 0.841; 95% CI, 0.511 to 1.39; P = 0.581) [35]. Here, ERBB2 is linked to breast cancer.