SMAD5 and osteosarcoma: miR-483-5p is overexpressed in osteoporotic patients and targets the downregulation of IGF2 expression [61], while miR-92b promotes cell proliferation and invasion in osteosarcoma by targeting DKK3 [62], and miR-155 inhibits osteoblast differentiation by downregulating the translation of SMAD5 in mouse pre-osteoblasts [63].