For instance, at least 10 pathways involved in pigmentation-related biology were identified, including Wnt/β-catenin signaling, MAPK signaling, melanogenesis, oxidative phosphorylation, cell cycle, TGF-beta signaling, melanoma, cAMP signaling, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, and Notch signaling (Fig. 7). This evidence concerns the gene EGFR and melanoma.