Long-term abnormal glucose and lipid metabolisms, as well as insulin resistance, can lead to cardiac microvascular endothelial cell proliferation, basement membrane thickening, oxygen utilization reduction, degeneration of heart myofibers and perivascular fibers, and deposition of intracoronary and intramyocardial glycoproteins, collagen fibers, triglycerides and cholesterol, all of which can result in coronary artery lumen stenosis, myocardial energy metabolism disorders, decreased systolic/diastolic function, and eventually lead to CAD and heart failure. The gene discussed is INS; the disease is heart failure.