FOXO1 and alveolar rhabdomyosarcoma: The experimental results of CHD4 and BRD4 inhibition in FP RMS cells resemble the effect of PAX3-FOXO1 depletion, providing a rationale for targeting transcriptional co-activators of PAX3-FOXO1, such as CHD4 and BRD4, as potential therapeutic targets in ARMS.