Administration of ApoE2 in ABCA1fl/fl stroke mice significantly increased Synaptophysin (Syn+, a presynaptic protein, employed herein as a marker of GM) density in the cortex in the ipsilateral brain, and increased Bielschowsky silver (BS+, an axon marker), phosphorylated high-molecular weight neurofilament (SMI31+, a marker of phosphorylated-neurofilament), and Luxol Fast Blue (LFB+, a myelin marker) densities in the corpus callosum (CC) in both the contralateral and the ipsilateral brain compared with administration of CFS in mice (Figure 2B, p < 0.05, n = 9/group). The gene discussed is SYP; the disease is stroke disorder.