However, the percentage of nestin+/BrdU+-cells (newly-formed NPCs) and the number of Sox2+ cells in the contralateral SVZ significantly increased, and the number of nestin+-/Sox2+ and nestin+-/Sox2+ double with BrdU+ cells in the ipsilateral SVZ significantly increased in ApoE2 administered ABCA1−B/−B stroke mice compared with CSF administered ABCA1−B/−B stroke mice. The gene discussed is NES; the disease is Stroke.