However, critical illnesses such as sepsis will alter the ecosystem of the body’s microbiota due to various pathophysiological (i.e., glucose and electrolyte disturbances, impairment in IgA production, loss of secreted antimicrobial peptides in the mucosal barrier or endogenous opioid production) and therapeutic (sedatives, opiates, and catecholamines) factors, and is clearly involved in the pathogenesis of subsequent frequent exacerbations [27]. Here, CD79A is linked to Sepsis.