Finally, the recent results from a collaborative genome-wide association study, examining more than 17,100 advanced AMD cases and 60,000 controls of European and Asian ancestry, have implicated TGFBR1, the gene coding for ALK5, in AMD pathogenesis due to an informative SNP within the sixth intron of the gene (p < 5 × 10−8) [115]. This evidence concerns the gene TGFBR1 and age-related macular degeneration.