TGFB1 and early-onset autosomal dominant Alzheimer disease: This link between AMD and Alzheimer’s disease, and the neuroprotective role of TGF-β, are also supported by the observation that retinal and circulating miRNAs miR-27a and miR-146a are upregulated in plasma of AMD patients and in the retina of amyloid-beta-injected rats, as well as in Alzheimer’s disease patients [105].