ITGAM and familial pancreatic carcinoma: Our data have demonstrated that combining smoothened inhibitor BMS833923 with MEK inhibitor AZD6244 is more effective in suppression of pancreatic cancer metastasis, as indicated by reduced the number of metastatic nodules (Figure 2), a decrease in cell proliferation (Figure 3) and reduced number of Ly6G+CD11b+ neutrophils (Figure S8).