The in vivo study was performed using male Kunming mice and the results indicated that treatment with fucoxanthin 38 remarkably reduce the expression of EGFR in the tumor tissue when compared with the model control group, suggesting that down-regulation of STAT3/EGFR signaling appeared to be involved in the in vivo anti-tumor effect and apoptosis induction [174]. Here, EGFR is linked to neoplasm.