Very recently, Sclafani et al. [142] analyzed the most frequently mutated KRAS hotspot mutation (i.e., G12D, G12V, and G13D) in rectal cancer tissue and corresponding plasma and did not observe much of a difference in the rate of KRAS mutation in plasma between patients with wild-type KRAS and KRAS-mutated tumors. Here, KRAS is linked to rectal cancer.