Moreover, AG490 significantly reduced the levels of OCT3/4 and β-catenin and the activity of MMP 9 in MDA-MB-231 and RT-R-MDA-MB-231 cells, effects that were similar to the inhibitory effects of oleandrin and odoroside A. Lastly, Figure 6 showed that STAT-3 inhibition by AG490 exhibited a similar effect of oleandrin (50 nM) and odoroside A (100 nM) on breast cancer cell invasion, indicating that the inhibition of STAT-3 phosphorylation by oleandrin and odoroside A mediates inhibition of breast cancer cell invasion. The gene discussed is STAT3; the disease is breast cancer.