These results have been corroborated by in vivo experiments using a mouse model of DLBCL dissemination from an intrahepatic xenograft to various organs [24] which showed that the inhibition of the Ca2+ channel activity of Orai1/STIM1 by BTP2 was inefficient to impair B cell dissemination in contrast to STIM1 under-expression. The gene discussed is ORAI1; the disease is diffuse large B-cell lymphoma.