However, our results demonstrate that extra (EGTA)- or intracellular (BAPTA-AM) Ca2+ chelator inhibiting Ca2+ release and Ca2+ entry signal in response to TG or SDF-1, as well as specific Orai1/STIM1 Ca2+ channel inhibitors, had no effect on basal or SDF-1-induced migration in tumor B cells which strongly suggest that intracellular Ca2+ increase is not required for B cell migration. Here, ORAI1 is linked to neoplasm.