However, in studies using a different PPAR-δ knockout mouse model targeting the C-terminal portion of the protein (Ppard exon 8), female KO mice treated with DSS showed significant increases in some clinical colitis scores (weight loss and colon length) as well as levels of IFN-γ, TNF-α, IL-6, and worsened histopathological scores compared to WT mice [76,77]. This evidence concerns the gene PPARD and colitis.