In addition, downregulation of PPAR-δ expression in cancer cells strongly suppressed metastases in orthotopic injection mouse models of multiple human cancers (e.g., colon, lung, melanoma, breast, and pancreas) via downregulation of important prometastatic genes (e.g., NRG1, CXCL8 (encoding IL-8), and STC1) in cancer cells and suppression of critical metastatic events including angiogenesis, epithelial-mesenchymal transition (EMT), and cancer cell invasion and migration [86] (Figure 1). Here, CXCL8 is linked to melanoma.